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Key Takeaway In a 72-week phase 3 trial of 238 Japanese adults with obesity-related disease, a once-daily oral pill called orforglipron reduced body weight…
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Key Takeaway In a 26-week randomized trial of 283 adults with type 2 diabetes who were not taking insulin, wearing a continuous glucose monitor…
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Key Takeaway In a real-world study of 6,286 adults aged 75 and older with type 2 diabetes, starting an SGLT2 inhibitor instead of a…
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Key Takeaway In patients with chronic kidney disease, suppressing aldosterone directly at its enzymatic source—rather than blocking its receptor downstream—lowered systolic blood pressure by…
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Key Takeaway The most comprehensive global registry on homozygous familial hypercholesterolemia reveals that, despite contemporary lipid-lowering therapies, 96% of patients fail to achieve LDL…
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Key Takeaways LITMUS confirms what many hepatologists have long suspected: routine individual blood markers cannot reliably identify treatment-eligible patients with at-risk MASH, whereas multi-marker…
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Key Takeaway In a nationwide Chinese cohort of 9,816 adults aged 45 and older, cognitive frailty was linked to roughly 2.5 to 2.7 times…
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Key Takeaway In a large-scale heart failure trial, moderate secondary mitral regurgitation was independently associated with an 11% increase in the risk of heart…
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Key Takeaway An oral NLRP3 inflammasome inhibitor, ruvonoflast, cut hsCRP by 82.2% over 28 days in obese adults at high cardiovascular risk, separating from…
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Key Takeaways Across 18,395 stroke survivors with atrial fibrillation pooled from six randomized controlled trials, apixaban emerged as the only blood thinner that significantly…
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Key Takeaway A critical review of recent phase III stroke trials finds a clear split. Brain-protecting drugs given within 24 hours, mostly alongside clot-removing…
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Key Takeaway An elevated high-sensitivity troponin shows that heart muscle has been injured. It does not show why. A new review in JACC argues…
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Key Takeaway In patients with advanced alcohol-associated liver disease deemed ineligible for liver transplantation, alcohol abstinence alone may not suffice. This multicenter cohort study…
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Executive Summary For years, we have stratified stroke risk in atrial fibrillation as though biology told the entire story. Drawing on UK Biobank data,…
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Key Takeaway In a randomized trial of 482 patients with heart block and normal pumping function, pacemakers that tap into the heart's own left-sided…
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